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Psychedelic Drugs: Types, Uses, and Effects Their data support the hypothesis that agonists acting at the same receptor in vivo can induce unique patterns of signaling, thereby eliciting different behavioral responses. Unique behavioral and signaling responses elicited by each agonist studied in vivo appear to result from agonist-specific differences in the activation of multiple signaling pathways coupled to the 5-HT2A receptor. Only the psychedelics DOI and LSD induced increased expression of egr-1, egr-2, and period-1 transcripts and were activated by changes in cortical signaling that appear to be specific effects of the two psychedelics, which correlate with the generation of the mouse HTR. For a long time, it was assumed that PI hydrolysis signaling was most relevant for the action of psychedelics, but this hypothesis has certain problems. Together, each of these studies indicates that agonism of 5-HT2A receptors may be a novel small molecule steroid-sparing therapeutic strate